IRAK3 (DD)

Full Name:
Interleukin-1 receptor-associated kinase 3
Alternative Names:
ASRT5, IRAKM, FLJ13601
Function:
Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity).
Death Domain Subfamily & Boundary Region:
  • DD : 41-106 Seq
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq Q9Y616external db link DIP-31799Nexternal db link Q9Y616external db link hsa:11213external db link Q9Y616external db link MINT-97148external db link
Mouse Seq Q8K4B2external db link Q8K4B2external db link mmu:73914external db link Q8K4B2external db link
Rat Seq B2RYC8external db link B2RYC8external db link rno:314870external db link
Dog Seq F1P664external db link
Zebra fish Seq Q4KMD6external db link
Not solved yet
Disease Mutation in disease Reference
Asthma susceptivility W76X 17503328
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DD IRAK3 Link IRAK1 Co-immunoprecipitation HEK293 Human Full length Not specified Full length 10383454
DD IRAK3 Link IRAK1 Co-immunoprecipitation HEK293 Not specified Not specified Mouse 1-550 19166926
DD IRAK3 Link IRAK1 Co-immunoprecipitation Mouse RAW 264.7 macrophage Not specified Not specified Mouse 1-550 19166926
DD IRAK3 Link IRAK1 Fluorescence resonance energy transfer NIH 3T3 Human Not specified Not specified Not specified 12138165
DD IRAK3 Link IRAK2 Co-immunoprecipitation HEK293 Human Full length Not specified Full length 10383454
DD IRAK3 Link IRAK3 Co-immunoprecipitation HEK293 Human Full length Human Full length 10383454
DD IRAK3 Link Myd88 Co-immunoprecipitation HEK293 Human Full length Not specified 1-151 10383454
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
DD IRAK3 Link IRAK1 Kinase assay IRAK3 activation 10383454
(Link: click this icon to show interactions only between the two corresponding DDs)