MALT1 (DD)

Full Name:
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Alternative Names:
MLT, MLT1, DKFZp434L132
Function:
Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.
Death Domain Subfamily & Boundary Region:
  • DD : 39-126 Seq
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq Q9UDY8external db link DIP-42833Nexternal db link Q9UDY8external db link hsa:10892external db link Q9UDY8external db link MINT-2844237external db link
Mouse Seq Q2TBA3external db link Q2TBA3external db link mmu:240354external db link
Rat Seq D4A7M2external db link rno:307366external db link
Dog Seq F1PVB7external db link
Zebra fish Seq Q9DDL2external db link dre:259196external db link
Structure Species Residue Method Expression Purification Column Final condition Final concentration Reference
2G7R Download Human X-ray
No information
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DD MALT1 Link FADD Co-immunoprecipitation Jurkat A3 15746428
DD MALT1 Link FADD Co-immunoprecipitation Caspase8 deficient Jurkat I9.2 15746428
(Link: click this icon to show interactions only between the two corresponding DDs)