MAVS (CARD)

Full Name:
Mitochondrial antiviral-signaling protein
Alternative Names:
IPS1, VISA, IPS-1, CARDIF, MGC3260, FLJ27482, FLJ35386, FLJ38051, FLJ41962, KIAA1271, DKFZp547C224, DKFZp666M015
Function:
Required for innate immune defense against viruses. Acts downstream of DDX58 and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.
Death Domain Subfamily & Boundary Region:
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq Q7Z434external db link DIP-35445Nexternal db link Q7Z434external db link hsa:57506external db link Q7Z434external db link MINT-3034048external db link
Mouse Seq Q8VCF0external db link
Rat Seq D4A9H1external db link
Dog Seq E2R2E4external db link
Structure Species Residue Method Expression Purification Column Final condition Final concentration Reference
2VGQ Download Human 1-93 X-ray E.coli Affinity chromatography(dialysis) 20mM tris(pH8.5), 100mM NaCl, 10mM maltose 10mg/ml 18307765
No information
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
CARD MAVS Link MAVS Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 19036819
CARD MAVS Link MAVS Fluorescence resonance energy transfer Huh 7 Not specified Not specified Not specified Not specified 19036819
CARD MAVS Link MDA5 Co-immunoprecipitation HEK293 Human Not specified Human 1-575 16127453
CARD MAVS Link RIG-1 Co-immunoprecipitation HEK293 Human Not specified Human 1-604 16127453
CARD MAVS Link RIG-1 Co-immunoprecipitation HEK293 Human Full length Not specified Not specified 16177806
CARD MAVS Link RIG-1 Co-immunoprecipitation HEK293 Human Not specified Not specified Not specified 17020950
CARD MAVS Link RIG-1 Co-immunoprecipitation HEK293 Not used Not specified Not specified 21419663
CARD MAVS Link RIG-1 Fluorescence resonance energy transfer Huh 7 Not specified Not specified Not specified Not specified 19036819
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
CARD MAVS Link MAVS Luciferase assay NF-kB activation 19036819
CARD MAVS Link MAVS Luciferase assay NF-kB activation 19036819
CARD MAVS Link MDA5 ELISA Type 1 interferon induced 16127453
CARD MAVS Link RIG-1 ELISA Type 1 interferon induced 16127453
CARD MAVS Link RIG-1 Luciferase assay IFN-b induced 16177806
(Link: click this icon to show interactions only between the two corresponding DDs)