NGFR (DD)

Full Name:
Tumor necrosis factor receptor superfamily member 16
Alternative Names:
CD271, p75NTR, TNFRSF16, p75(NTR), Gp80-LNGFR
Function:
Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
Death Domain Subfamily & Boundary Region:
  • DD : 344-421 Seq
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq P08138external db link DIP-406Nexternal db link P08138external db link hsa:4804external db link P08138external db link MINT-107412external db link
Mouse Seq Q9Z0W1external db link Q9Z0W1external db link MINT-243918external db link
Rat Seq P07174external db link DIP-5715Nexternal db link P07174external db link rno:24596external db link P07174external db link MINT-128759external db link
Dog Seq F1PAR7external db link
Zebra fish Seq F1R841external db link
Structure Species Residue Method Expression Purification Column Final condition Final concentration Reference
1NGR Download Rat 334-418 NMR E.coli Gel filtration Superose 12 2.5mM 0
No information
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DD NGFR Link IRAK1 Co-immunoprecipitation PC12 12034707
DD NGFR Link Myd88 Co-immunoprecipitation PC12 12034707
DD NGFR Link TRADD Co-Immunofluorescence staining MCF-7 12604596
DD NGFR Link TRADD Co-immunoprecipitation MCF-7 12604596
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
DD NGFR Link IRAK1 Luciferase assay NF-kB activation 12034707
DD NGFR Link TRADD Co-Immunofluorescence staining NF-kB activation 12604596
(Link: click this icon to show interactions only between the two corresponding DDs)