NLRP1 (PYD)

Full Name:
NACHT, LRR and PYD domains-containing protein 1
Alternative Names:
NAC, CARD7, NALP1, SLEV1, DEFCAP, PP1044, VAMAS1, CLR17.1, KIAA0926, DEFCAP-L/S, DKFZp586O1822
Function:
Able to form cytoplasmic structures termed death effector filaments. Enhances APAF1 and cytochrome c-dependent activation of pro-caspase-9 and consecutive apoptosis. Stimulates apoptosis through activation of caspase-3. Involved in activation of caspase-1 and caspase-5 as part of the NALP1 inflammasome complex which leads to processing and release of IL1B and IL18. Binds ATP.
Death Domain Subfamily & Boundary Region:
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq Q9C000external db link DIP-38407Nexternal db link Q9C000external db link hsa:22861external db link Q9C000external db link
Mouse Seq Q2LKU9external db link Q2LKU9external db link mmu:195046external db link
Rat Seq D9I2G4external db link
Dog Seq E2R3A5external db link
Structure Species Residue Method Expression Purification Column Final condition Final concentration Reference
1PN5 Download Human 1-92 NMR E.coli Gel filtration Suphadex 75 26/60 50mM Na2HPO4(pH6.5), 50mM NaCl, 1mM CHAPS, 20mM DTT, 0.02% NaN3, 0.1mM EDTA 1mM 14527388
Disease Mutation in disease Reference
Vitiligo associated multiple autoimmune disease (VAMAS1) L155H 17377159
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
PYD NLRP1 Link POP2 Yeast two-hybrid Not specified Not specified Yeast Human Not specified Yeast 17178784
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
PYD NLRP1 Link ASC Co-immunoprecipitation THP-1 17418785
PYD NLRP1 Link ASC Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 17418785
PYD NLRP1 Link ASC Co-immunoprecipitation Rat cortical lysate 19401709
PYD NLRP1 Link ASC Size-exclusion chromatography Mice cerebral cortex 19066616
PYD NLRP1 Link NLRP2 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Full length 15456791
(Link: click this icon to show interactions only between the two corresponding DDs)