NLRP10 (PYD)

Full Name:
NACHT, LRR and PYD domains-containing protein 10
Alternative Names:
NOD8, PAN5, PYNOD, NALP10, CLR11.1
Function:
Inhibits CASP1/caspase-1-dependent IL1B secretion and PYCARD-mediated apoptosis, but not that induced by FAS or BID.
Death Domain Subfamily & Boundary Region:
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq Q86W26external db link Q86W26external db link hsa:338322external db link
Mouse Seq Q8CCN1external db link Q8CCN1external db link mmu:244202external db link
Rat Seq D3ZUA2external db link rno:293426external db link
Dog Seq E2RMV7external db link
Structure Species Residue Method Expression Purification Column Final condition Final concentration Reference
2DO9 Download Mouse NMR
No information
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
PYD NLRP10 Link ASC Co-Immunofluorescence staining HEK293 20393137
PYD NLRP10 Link ASC Co-immunoprecipitation HEK293 Human Not specified Human Not specified 15096476
PYD NLRP10 Link NLRP10 Co-immunoprecipitation HEK293 Human Not specified Human Not specified 15096476
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
PYD NLRP10 Link ASC Propidium iodide-Annexin V staining, Luciferase assay, Immunostaining Apoptosis inhibition NF-kB-activation block, ASC aggregation inhibition 20393137
PYD NLRP10 Link ASC Annexin V staining, EMSA ASC mediated Apoptosis block NF-kB-activation block 15096476
(Link: click this icon to show interactions only between the two corresponding DDs)