NLRP12 (PYD)

Full Name:
NACHT, LRR and PYD domains-containing protein 12
Alternative Names:
RNO, PAN6, RNO2, FCAS2, NALP12, PYPAF7, CLR19.3
Function:
May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.
Death Domain Subfamily & Boundary Region:
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq P59046external db link DIP-41453Nexternal db link P59046external db link hsa:91662external db link MINT-237788external db link
Mouse Seq Q14BA2external db link Q14BA2external db link
Rat Seq D4A399external db link rno:292541external db link
Dog Seq E2R230external db link
Structure Species Residue Method Expression Purification Column Final condition Final concentration Reference
2L6A Download Human 1-98 NMR 21978668
Disease Mutation in disease Reference
Familial cold autoinflammatory syndrome R284X, V635fs 18230725
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
PYD NLRP12 Link ASC Co-Immunofluorescence staining HEK293 Not specified Full length Not specified Not specified 12019269
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
PYD NLRP12 Link ASC Luciferase assay, ELISA NF-kB activation, IL-1b secretion 12019269
(Link: click this icon to show interactions only between the two corresponding DDs)