NLRP2 (PYD)

Full Name:
NACHT, LRR and PYD domains-containing protein 2
Alternative Names:
NBS1, PAN1, NALP2, PYPAF2, CLR19.9, FLJ20510
Function:
Suppresses TNF-and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.
Death Domain Subfamily & Boundary Region:
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq Q9NX02external db link DIP-42460Nexternal db link Q9NX02external db link hsa:55655external db link MINT-5006655external db link
Mouse Seq Q4PLS0external db link Q4PLS0external db link mmu:232827external db link
Not solved yet
No information
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
PYD NLRP2 Link ASC Co-immunoprecipitation Human 1-93 HEK293 THP-1 lysate 15030775
PYD NLRP2 Link POP2 GST fusion protein pull-down Not specified Not specified In vitro translation Not specified Human E.coli 17178784
PYD NLRP2 Link POP2 GST fusion protein pull-down Not specified Not specified In vitro translation Human Not specified E.coli 17178784
PYD NLRP2 Link POP2 Yeast two-hybrid Not specified Not specified Yeast Human Not specified Yeast 17178784
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
PYD NLRP2 Link ASC Co-immunoprecipitation HEK293 Human 1-93 Not specified Not specified 15030775
PYD NLRP2 Link ASC Co-immunoprecipitation THP-1 Human Full length Not used 15030775
PYD NLRP2 Link ASC Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 15456791
PYD NLRP2 Link ASC Co-immunoprecipitation HEK293 Not specified Full length Not specified Not specified 15456791
PYD NLRP2 Link NLRP1 Co-immunoprecipitation HEK293 Not specified Full length Not specified Not specified 15456791
PYD NLRP2 Link POP2 Co-Immunofluorescence staining HEK293 Not specified Not specified Human Not specified 17178784
PYD NLRP2 Link POP2 Co-immunoprecipitation HEK293 Not specified Not specified Human Not specified 17178784
PYD NLRP2 Link POP2 Co-immunoprecipitation HEK293 Not specified Not specified Not used Not specified 17178784
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Characterization
  Stoichiometry Affinity Protein-Protein interface Reference
Family DD1 DD2 Method Mutation Complex structure
PYD NLRP2 Link ASC Co-immunoprecipitation E13W (ASC) 15456791
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
PYD NLRP2 Link ASC ELISA IL-1b secretion (Inflammasome) 15456791
PYD NLRP2 Link POP2 ELISA IL-1b secretion decrease 17178784
(Link: click this icon to show interactions only between the two corresponding DDs)