NLRP7 (PYD)

Full Name:
NACHT, LRR and PYD domains-containing protein 7
Alternative Names:
HYDM, PAN7, NALP7, NOD12, PYPAF3, CLR19.4, FLJ94610, MGC126470, MGC126471
Function:
Inhibits CASP1/caspase-1-dependent IL1B secretion.
Death Domain Subfamily & Boundary Region:
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq Q8WX94external db link Q8WX94external db link hsa:199713external db link
Structure Species Residue Method Expression Purification Column Final condition Final concentration Reference
2KM6 Download Human 1-96 NMR E.coli Gel filtration Superdex 75 20mM sodium phosphate(pH6.0), 50mM NaCl, 0.25mM TCEP 20547486
Disease Mutation in disease Reference
Hydatidiform mole 10951527
Hydatidiform mole 16239310
Hydatidiform mole R693P 16462743
Hydatidiform mole R432X 19066229
Hydatidiform mole T61fs, E113fs, Y318fs, R432X, E570X, L677fs, P716fs, P651S, R693Q, P716A, R721W, C761Y, N913S 19246479
Hydatidiform mole R693P, N913S 19650864
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
PYD NLRP7 Link ASC Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 22361007
(Link: click this icon to show interactions only between the two corresponding DDs)