PEA15 (DED)

Full Name:
Astrocytic phosphoprotein PEA-15
Alternative Names:
PED, MAT1, HMAT1, MAT1H, PEA-15, HUMMAT1H
Function:
Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6-and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.
Death Domain Subfamily & Boundary Region:
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq Q15121external db link DIP-40820Nexternal db link Q15121external db link hsa:8682external db link Q15121external db link MINT-141556external db link
Mouse Seq Q62048external db link Q62048external db link mmu:18611external db link
Rat Seq Q5U318external db link rno:364052external db link
Dog Seq F1PIK5external db link
Zebra fish Seq E7FEH9external db link dre:557745external db link
Structure Species Residue Method Expression Purification Column Final condition Final concentration Reference
1N3K Download Cricetulus griseus 1-130 NMR E.coli Ion Exchange MonoQ HR 16/10 10mM sodium phosphate(pH 7.0), 50 mM NaN3, 1mM DTT 1mM 12456656
2LS7 Download Mouse 1-90 NMR E.coli Ion Exchange MonoQ HR 16/10 9mg/ml 22732408
No information
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
DED PEA15 Link FADD GST fusion protein pull-down Not specified Not specified In vitro translation Not specified Not specified In vitro translation 10493725
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DED PEA15 Link Caspase8 Co-immunoprecipitation HeLa Human Full length Human Not specified 10442631
DED PEA15 Link FADD Co-immunoprecipitation HeLa Human Full length Human 1-208 10442631
DED PEA15 Link FADD Co-immunoprecipitation LNCaP 22179576
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
DED PEA15 Link Caspase8 PARP cleaved assay Apoptosis inhibition 10442631
DED PEA15 Link FADD DAPI, Annexin V staining, TUNEL assay Apoptosis inhibition 10493725
(Link: click this icon to show interactions only between the two corresponding DDs)