POP2 (PYD)

Full Name:
Pyrin domain-containing protein 2
Alternative Names:
cPOP2, PYDC2
Function:
Inhibits NF-kappa-B signaling distally by affecting the nuclear accumulation of RELA. Disrupts the interaction between PYCARD and NLRP3.
Death Domain Subfamily & Boundary Region:
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq Q56P42external db link hsa:152138external db link
Not solved yet
No information
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
PYD POP2 Link ASC GST fusion protein pull-down Not specified Human E.coli Human Not specified In vitro translation 17178784
PYD POP2 Link ASC GST fusion protein pull-down Human Not specified E.coli Not specified Human In vitro translation 17178784
PYD POP2 Link ASC Yeast two-hybrid Human Not specified Yeast Human Not specified Yeast 17178784
PYD POP2 Link NLRP1 Yeast two-hybrid Human Not specified Yeast Not specified Not specified Yeast 17178784
PYD POP2 Link NLRP2 GST fusion protein pull-down Not specified Human E.coli Not specified Not specified In vitro translation 17178784
PYD POP2 Link NLRP2 GST fusion protein pull-down Human Not specified E.coli Not specified Not specified In vitro translation 17178784
PYD POP2 Link NLRP2 Yeast two-hybrid Human Not specified Yeast Not specified Not specified Yeast 17178784
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
PYD POP2 Link ASC Co-Immunofluorescence staining HEK293 Human Not specified Human Not specified 17178784
PYD POP2 Link ASC Co-Immunofluorescence staining HeLa Human Not specified Not specified Not specified 17339483
PYD POP2 Link ASC Co-immunoprecipitation HEK293 Human Not specified Human Not specified 17178784
PYD POP2 Link NLRP2 Co-Immunofluorescence staining HEK293 Human Not specified Not specified Not specified 17178784
PYD POP2 Link NLRP2 Co-immunoprecipitation HEK293 Human Not specified Not specified Not specified 17178784
PYD POP2 Link NLRP2 Co-immunoprecipitation HEK293 Not used Not specified Not specified Not specified 17178784
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
PYD POP2 Link ASC ELISA IL-1b secretion decrease 17178784
PYD POP2 Link ASC Immunofluorescence staining Inflammasome inhibition 17339483
PYD POP2 Link NLRP2 ELISA IL-1b secretion decrease 17178784
(Link: click this icon to show interactions only between the two corresponding DDs)