PYHIN1 (PYD)

Full Name:
Pyrin and HIN domain-containing protein 1
Alternative Names:
IFIX, MGC23885, RP11-520H16.1
Function:
Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells.
Death Domain Subfamily & Boundary Region:
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq Q6K0P9external db link Q6K0P9external db link hsa:149628external db link
Mouse Seq Q8BV49external db link mmu:236312external db link
Not solved yet
No information
Question There is no death-domain PPI with PYHIN1 in Death Domain PYD subfamily.