- At a glance
- In detail
- Full Name:
- Pyrin and HIN domain-containing protein 1
- Alternative Names:
- IFIX, MGC23885, RP11-520H16.1
- Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells.
- Death Domain Subfamily & Boundary Region:
- PYD : 1-88
Not solved yet
There is no death-domain PPI with PYHIN1 in Death Domain PYD subfamily.