Pyrin (PYD)

Full Name:
Pyrin
Alternative Names:
FMF, MEF, TRIM20, MGC126560, MGC126586, MEFV
Function:
Probably controls the inflammatory response in myelomonocytic cells at the level of the cytoskeleton organization.
Death Domain Subfamily & Boundary Region:
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq O15553external db link DIP-41878Nexternal db link O15553external db link hsa:4210external db link MINT-206922external db link
Mouse Seq Q9JJ26external db link Q9JJ26external db link
Rat Seq Q9JJ25external db link Q9JJ25external db link rno:58923external db link
Dog Seq F1PEK8external db link
Not solved yet
Disease Mutation in disease Reference
Familial mediterranean fever M694V, M680I, E148Q, V726A 1146248
Familial mediterranean fever 7677151
Familial mediterranean fever M680I, M694V, V726A 9288758
Familial mediterranean fever E148Q, E167D, T267I, F479L, I692del, K695R, A744S, R761H 9668175
Familial mediterranean fever M694V 9781020
Familial mediterranean fever M680I, P369S 10090880
Familial mediterranean fever R408Q 10364520
Familial mediterranean fever M694I, M694del 10787449
Familial mediterranean fever R653H 11242116
Familial mediterranean fever E148V, E148Q 11903360
Familial mediterranean fever H478Y 14679589
Familial mediterranean fever E167D, F479L 19863562
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
PYD Pyrin Link ASC His fusion protein pull-down Not specified Full length Sf-9 Human Full length HEK293 16037825
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
PYD Pyrin Link ASC Co-Immunofluorescence staining HeLa Not specified Not specified Not specified Not specified 11498534
PYD Pyrin Link ASC Co-Immunofluorescence staining PT67 Mouse Full length Mouse Full length 12667444
PYD Pyrin Link ASC Co-immunoprecipitation HEK293 Not specified Full length Human Not specified 12615073
PYD Pyrin Link ASC Co-immunoprecipitation HEK293 Not specified Not specified Human Full length 16037825
PYD Pyrin Link ASC GST fusion protein pull-down PT67 Mouse Not specified Mouse Full length 12667444
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
PYD Pyrin Link ASC DAPI staining Apoptosis inhibition 11498534
PYD Pyrin Link ASC Apoptotic DNA ladder assay Apoptosis inhibition 12667444
PYD Pyrin Link ASC β-galactosidase staining, Luciferase assay Apoptosis inhibition NLRP3-ASC mediated NF-kB activation block 12615073
PYD Pyrin Link ASC Caspase cleaved assay Caspase1 activation (Inflammasome) 16037825
(Link: click this icon to show interactions only between the two corresponding DDs)