- At a glance
- In detail
- Full Name:
- Tumor necrosis factor receptor superfamily member 11B
- Alternative Names:
- OPG, TR1, OCIF, MGC29565
- Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.
- Death Domain Subfamily & Boundary Region:
- DD : 270-365
Not solved yet
There is no death-domain PPI with TNFRSF11B in Death Domain DD subfamily.