TNFRSF11B (DD)

Full Name:
Tumor necrosis factor receptor superfamily member 11B
Alternative Names:
OPG, TR1, OCIF, MGC29565
Function:
Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.
Death Domain Subfamily & Boundary Region:
  • DD : 270-365 Seq
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq O00300external db link O00300external db link hsa:4982external db link
Mouse Seq O08712external db link O08712external db link mmu:18383external db link
Rat Seq O08727external db link O08727external db link rno:25341external db link
Dog Seq E2QRR0external db link
Not solved yet
Disease Mutation in disease Reference
Paget disease 12124406
Paget disease 12189164
Paget disease F117L, C87Y, C65R, D182del, D198del 14672344
Question There is no death-domain PPI with TNFRSF11B in Death Domain DD subfamily.