UNC5B (DD)

Full Name:
Netrin receptor UNC5B
Alternative Names:
UNC5H2, p53RDL1
Function:
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
Death Domain Subfamily & Boundary Region:
  • DD : 865-943 Seq
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq Q8IZJ1external db link DIP-46275Nexternal db link Q8IZJ1external db link hsa:219699external db link
Mouse Seq Q8K1S3external db link Q8K1S3external db link mmu:107449external db link
Rat Seq O08722external db link O08722external db link rno:60630external db link
Dog Seq E2RC29external db link
Zebra fish Seq A3KPR8external db link
Structure Species Residue Method Expression Purification Column Final condition Final concentration Reference
1WMG Download Mouse 854-943 X-ray 17139086
3G5B Download Rat 543-943 X-ray E.coli Gel filtration Superose 12 50mM tris-HCl(pH7.5), 100mM NaCl, 1mM DTT 19328064
No information
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DD UNC5B Link DAPK1 Co-immunoprecipitation HEK293 Not specified Full length Not specified Full length 15729359
DD UNC5B Link DAPK1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Full length 15729359
DD UNC5B Link DAPK1 Co-immunoprecipitation HEK293 Not specified 841-945 Not specified Full length 15729359
DD UNC5B Link DAPK1 Co-immunoprecipitation HEK293 Not specified 631-945 Not specified Full length 15729359
DD UNC5B Link DAPK1 Co-immunoprecipitation HEK293 Not specified Full length Not specified 1301-1431 15729359
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
DD UNC5B Link DAPK1 Trypan blue staining, Immunoprecipitation Apoptosis, DAPK kinase activity increase 15729359
(Link: click this icon to show interactions only between the two corresponding DDs)