UNC5C (DD)

Full Name:
Netrin receptor UNC5C
Alternative Names:
UNC5H3
Function:
Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. Axon repulsion in growth cones may be caused by its association with DCC that may trigger signaling for repulsion. Also involved in corticospinal tract axon guidances independently of DCC. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity).
Death Domain Subfamily & Boundary Region:
  • DD : 850-929 Seq
Species External DB Questionmark
Uniprot DIP STRING KEGG IntAct MINT
Human Seq O95185external db link DIP-46276Nexternal db link O95185external db link hsa:8633external db link
Mouse Seq O08747external db link O08747external db link mmu:22253external db link
Rat Seq Q761X5external db link Q761X5external db link rno:362049external db link
Dog Seq F1PUW2external db link
Zebra fish Seq A5WZG3external db link
Not solved yet
No information
Question There is no death-domain PPI with UNC5C in Death Domain DD subfamily.