J Biol Chem. 1999 Jun 11;274(24):16871-5.

RIP3, a novel apoptosis-inducing kinase.External

Sun, X., Lee, J., Navas, T., Baldwin, D. T., Stewart, T. A., Dixit, V. M.,
--- - Departments of Molecular Oncology, Genentech, Inc., South San Francisco, California 94080, USA.
RIP3 is a novel gene product containing a N-terminal kinase domain that shares extensive homology with the corresponding domain in RIP (receptor-interacting protein) and RIP2. Unlike RIP, which has a C-terminal death domain, and RIP2, which has a C-terminal caspase activation and recruitment domain, RIP3 has a unique C terminus. RIP3 binds RIP through its unique C-terminal segment and by virtue of this interaction is recruited to the tumor necrosis factor (TNF) receptor-1 signaling complex. Previous studies have shown that RIP mediates TNF-induced activation of the anti-apoptotic NF-kappaB pathway. RIP3, however, attenuates both RIP and TNF receptor-1-induced NF-kappaB activation. Overexpression studies revealed RIP3 to be a potent inducer of apoptosis, capable of selectively binding to large prodomain initiator caspases.
PMID: 10358032External
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DD RIP Link TNFR1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 10358032
DD TNFR1 Link TRADD Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 10358032
(Link: click this icon to show interactions only between the two corresponding DDs)