Biochim Biophys Acta. 2000 May 23;1478(2):280-8.

LRDD, a novel leucine rich repeat and death domain containing protein.External

Telliez, J. B., Bean, K. M., Lin, L. L.,
--- - Small Molecule Drug Discovery Group, Genetics Institute, Inc., 87 CambridgePark Drive, 02140, Cambridge, MA 02140, USA.
Death domains (DD) and leucine rich repeats (LRR) are two different types of protein interaction motifs. Death domains are found predominantly in proteins involved in signaling and are involved in homo- and heteromultimerization. Leucine rich repeats are found in proteins with diverse cellular functions, like cell adhesion and cellular signaling, and mediate reversible protein-protein interactions. In this paper we report the cloning of a new human gene called LRDD (leucine repeat death domain containing protein). LRDD encodes a protein of 83 kDa with six LRRs at the N-terminus and a DD at the C-terminus. LRDD appears to be processed into two fragments of about 33 and 55 kDa, containing LRRs and DD respectively. Interestingly, LRDD is shown to interact with two other death domain containing proteins, FADD and MADD, presumably through death domain interactions. LRDD may represent a new type of adapter protein that could be involved in signaling or other cellular functions.
PMID: 10825539External
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DD FADD Link PIDD Co-immunoprecipitation COS-7 Not specified Not specified Not specified 1-753 10825539
DD MADD Link PIDD Co-immunoprecipitation COS-7 Not specified Not specified Not specified 1-753 10825539
(Link: click this icon to show interactions only between the two corresponding DDs)