Biochem Biophys Res Commun. 2000 Oct 22;277(2):513-7.

The serine/threonine kinase HIPK2 interacts with TRADD, but not with CD95 or TNF-R1 in 293T cells.External

Li, X., Wang, Y., Debatin, K. M., Hug, H.,
--- - Universitats-Kinderklinik Ulm, Prittwitzstrasse 43, Ulm, D-89075, Germany.
HIPK2 has been described as a homoedomain-interacting protein kinase with a nuclear localization. Here we describe that HIPK2 can also associate with TRADD, a protein that interacts with tumor necrosis factor receptor type 1 (TNF-R1). Under the conditions where HIPK2/TRADD association was found, no direct interaction of HIPK2 with CD95, TNF-R1, FADD or caspase-8 could be detected. Therefore, HIPK2 may play a role in TNF-R1 mediated signaling.
PMID: 11032752External
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DD FADD Link Fas Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 11032752
DD Fas Link TRADD Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 11032752
(Link: click this icon to show interactions only between the two corresponding DDs)