Genomics. 2001 Jul;75(1-3):77-83.

CLAN, a novel human CED-4-like gene.External

Damiano, J. S., Stehlik, C., Pio, F., Godzik, A., Reed, J. C.,
--- - The Burnham Institute, La Jolla, California 92037, USA.
Proteins governing cell death form the basis of many normal processes and contribute to the pathogenesis of many diseases when dysregulated. Here we report the cloning of a novel human CED-4-like gene, CLAN, and several of its alternatively spliced isoforms. These caspase-associated recruitment domain (CARD)-containing proteins are expressed at varying degrees in normal human tissues and may contribute to a number of intracellular processes including apoptosis, cytokine processing, and NF-kappa B activation. The CARD of the CLAN proteins binds a number of other CARD-containing proteins including caspase-1, BCL10, NOD2, and NAC. Once their physiologic functions are uncovered, CLAN proteins may prove to be valuable therapeutic targets.
PMID: 11472070External
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
CARD Bcl-10 Link CARD12 Co-immunoprecipitation HEK293 Not specified Not specified Human Not specified 11472070
CARD CARD12 Link CARD12 Co-immunoprecipitation HEK293 Human Not specified Human Not specified 11472070
CARD CARD12 Link Caspase1 Co-immunoprecipitation HEK293 Human Not specified Not specified Not specified 11472070
CARD CARD12 Link NLRP1 Co-immunoprecipitation HEK293 Human Not specified Not specified Not specified 11472070
CARD CARD12 Link NOD2 Co-immunoprecipitation HEK293 Human Not specified Not specified Not specified 11472070
(Link: click this icon to show interactions only between the two corresponding DDs)