Science. 1996 Nov 8;274(5289):990-2.

Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95.External

Chinnaiyan, A. M., O'Rourke, K., Yu, G. L., Lyons, R. H., Garg, M., Duan, D. R., Xing, L., Gentz, R., Ni, J., Dixit, V. M.,
--- - Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Sciences Inc., 9620 Medical Center Driv.
Tumor necrosis factor receptor-1 (TNFR-1) and CD95 (also called Fas or APO-1) are cytokine receptors that engage the apoptosis pathway through a region of intracellular homology, designated the "death domain." Another death domain-containing member of the TNFR family, death receptor 3 (DR3), was identified and was shown to induce both apoptosis and activation of nuclear factor kappaB. Expression of DR3 appears to be restricted to tissues enriched in lymphocytes. DR3 signal transduction is mediated by a complex of intracellular signaling molecules including TRADD, TRAF2, FADD, and FLICE. Thus, DR3 likely plays a role in regulating lymphocyte homeostasis.
PMID: 8875942External
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vitro interaction
  DD1 DD2 Reference
Family DD1 DD2 Method Species Region Expression Species Region Expression
DD DR3 Link TRADD GST fusion protein pull-down Human 215-393 E.coli Not specified Not specified In vitro translation 8875942
DD FADD Link Fas GST fusion protein pull-down Not specified Not specified In vitro translation Not specified Not specified E.coli 8875942
DD TNFR1 Link TRADD GST fusion protein pull-down Not specified Not specified E.coli Not specified Not specified In vitro translation 8875942
(Link: click this icon to show interactions only between the two corresponding DDs)