Science. 1997 Apr 4;276(5309):111-3.

The receptor for the cytotoxic ligand TRAIL.External

Pan, G., O'Rourke, K., Chinnaiyan, A. M., Gentz, R., Ebner, R., Ni, J., Dixit, V. M.,
--- - Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
TRAIL (also known as Apo-2L) is a member of the tumor necrosis factor (TNF) ligand family that rapidly induces apoptosis in a variety of transformed cell lines. The human receptor for TRAIL was found to be an undescribed member of the TNF-receptor family (designated death receptor-4, DR4) that contains a cytoplasmic "death domain" capable of engaging the cell suicide apparatus but not the nuclear factor kappa B pathway in the system studied. Unlike Fas, TNFR-1, and DR3, DR4 could not use FADD to transmit the death signal, suggesting the use of distinct proximal signaling machinery. Thus, the DR4-TRAIL axis defines another receptor-ligand pair involved in regulating cell suicide and tissue homeostasis.
PMID: 9082980External
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DD FADD Link Fas Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 9082980
DD RIP Link TNFR1 Co-immunoprecipitation HEK293 Not specified 37-205 Not specified Not specified 9082980
DD RIP Link TNFR1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified 37-205 9082980
DD TNFR1 Link TRADD Co-immunoprecipitation HEK293 Not specified 37-205 Not specified Not specified 9082980
(Link: click this icon to show interactions only between the two corresponding DDs)