J Biol Chem. 1997 Oct 10;272(41):25783-6.

Ultraviolet radiation-induced apoptosis is mediated by activation of CD-95 (Fas/APO-1).External

Rehemtulla, A., Hamilton, C. A., Chinnaiyan, A. M., Dixit, V. M.,
--- - Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA.
Exposure to ultraviolet light (UV) can induce apoptosis in mammalian cells. The mechanism by which UV radiation engages the suicide apparatus is unclear. Here we demonstrate that UV radiation can activate the Fas pathway via receptor aggregation and subsequent recruitment of the death adaptor molecule FADD/MORT1. UV radiation-induced apoptosis was inhibited by both a dominant negative version of FADD (FADD-DN) and the caspase inhibitor CrmA. Thus, activation of the Fas pathway represents a physiologic mechanism by which UV-damaged cells are eliminated.
PMID: 9325306External
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DD FADD Link Fas Co-immunoprecipitation BJAB 9325306
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
DD FADD Link Fas Propidium iodide staining Apoptosis (DISC) 9325306
(Link: click this icon to show interactions only between the two corresponding DDs)