Science. 1997 Nov 28;278(5343):1612-5.

IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling.External

Muzio, M., Ni, J., Feng, P., Dixit, V. M.,
--- - University of Michigan Medical School, Department of Pathology, Ann Arbor, MI 48109, USA.
The interleukin-1 receptor (IL-1R) signaling pathway leads to nuclear factor kappa B (NF-kappaB) activation in mammals and is similar to the Toll pathway in Drosophila: the IL-1R-associated kinase (IRAK) is homologous to Pelle. Two additional proximal mediators were identified that are required for IL-1R-induced NF-kappaB activation: IRAK-2, a Pelle family member, and MyD88, a death domain-containing adapter molecule. Both associate with the IL-1R signaling complex. Dominant negative forms of either attenuate IL-1R-mediated NF-kappaB activation. Therefore, IRAK-2 and MyD88 may provide additional therapeutic targets for inhibiting IL-1-induced inflammation.
PMID: 9374458External
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DD IRAK2 Link Myd88 Co-immunoprecipitation HEK293 Human Full length Human Full length 9374458
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
DD IRAK2 Link Myd88 Luciferase assay NF-kB activation (Myddosome) 9374458
(Link: click this icon to show interactions only between the two corresponding DDs)