Immunity. 1997 Dec;7(6):831-6.

TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB.External

Schneider, P., Thome, M., Burns, K., Bodmer, J. L., Hofmann, K., Kataoka, T., Holler, N., Tschopp, J.,
--- - Institute of Biochemistry, University of Lausanne, Switzerland.
TRAIL induces apoptosis through two closely related receptors, TRAIL-R1 (DR4) and TRAIL-R2 (DR5). Here we show that TRAIL-R1 can associate with TRAIL-R2, suggesting that TRAIL may signal through heteroreceptor signaling complexes. Both TRAIL receptors bind the adaptor molecules FADD and TRADD, and both death signals are interrupted by a dominant negative form of FADD and by the FLICE-inhibitory protein FLIP. The recruitment of TRADD may explain the potent activation of NF-kappaB observed by TRAIL receptors. Thus, TRAIL receptors can signal both death and gene transcription, functions reminiscent of those of TNFR1 and TRAMP, two other members of the death receptor family.
PMID: 9430228External
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DD DR4 Link FADD Co-immunoprecipitation HEK293 Not specified 261-465 Not specified 80-208 9430228
DD DR4 Link TRADD Co-immunoprecipitation HEK293 Not specified 261-465 Not specified Not specified 9430228
DD DR5 Link FADD Co-immunoprecipitation HEK293 Not specified 232-439 Not specified 80-208 9430228
DD DR5 Link TRADD Co-immunoprecipitation HEK293 Not specified 261-465 Not specified Not specified 9430228
DD DR5 Link TRADD Co-immunoprecipitation HEK293 Not specified 232-439 Not specified Not specified 9430228
(Link: click this icon to show interactions only between the two corresponding DDs)
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
Functional Role
Family DD1 DD2 Method Death-related Death-unrelated Reference
DD DR4 Link FADD Cytoplasmic histone associated DNA fragment detection Apoptosis (DISC) 9430228
DD DR5 Link FADD Cytoplasmic histone associated DNA fragment detection Apoptosis (DISC) 9430228
(Link: click this icon to show interactions only between the two corresponding DDs)