FEBS Lett. 1998 Jul 24;431(3):351-6.

Identification and functional characterization of DR6, a novel death domain-containing TNF receptor.External

Pan, G., Bauer, J. H., Haridas, V., Wang, S., Liu, D., Yu, G., Vincenz, C., Aggarwal, B. B., Ni, J., Dixit, V. M.,
--- - Department of Pathology, University of Michigan Medical School, Ann Arbor 48109, USA. jgpan@gene.com
Tumor nectosis factor (TNF) receptors are key players in inflammation and immune regulation. A new member of this family, termed death receptor-6 (DR6), has been identified. Like other death receptors, DR6 is a type I transmembrane receptor, possesses four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is expressed in most human tissues and abundant transcript was detected in heart, brain, placenta, pancreas, thymus, lymph node and several non-lymphoid cancer cell lines. DR6 interacts with TRADD, which has previously been shown to associate with TNFR1. Furthermore, ectopic expression of DR6 in mammalian cells induces apoptosis and activation of both NF-kappaB and JNK.
PMID: 9714541External
Arrow2 In vitro interaction Arrow2 In vivo interaction Arrow2 Characterization Arrow2 Functional role Arrow2 top
In vivo interaction
  Endogenous
expression
Overexpression DD1 DD2 Reference
Family DD1 DD2 Method Species Region Species Region
DD DR3 Link TRADD Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 9714541
DD DR6 Link TRADD Co-immunoprecipitation HEK293 Not specified 42-655 Not specified Not specified 9714541
DD FADD Link Fas Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 9714541
DD RIP Link TNFR1 Co-immunoprecipitation HEK293 Not specified Not specified Not specified Not specified 9714541
(Link: click this icon to show interactions only between the two corresponding DDs)