Death Domain (DD) superfamily

Number of PPI pairs: 181
(Link: click this icon to show interactions only between the two corresponding DDs)
Family DD1   DD2 Interaction Characterization Functional Role
In vitro In vivo
CARD Apaf1 in detail see interaction Caspase9 in detail Checked Checked Checked Checked
CARD Apaf1 in detail see interaction Caspase4 in detail Checked
CARD Apaf1 in detail see interaction Apaf1 in detail Checked Checked Checked
CARD Apaf1 in detail see interaction NLRP1 in detail Checked Checked Checked
CARD Apaf1 in detail see interaction Caspase2 in detail Checked
CARD ASC in detail see interaction ASC in detail Checked Checked
CARD ASC in detail see interaction CARD12 in detail Checked Checked Checked
CARD ASC in detail see interaction Caspase1 in detail Checked Checked Checked Checked
CARD ASC in detail see interaction CARD16 in detail Checked
CARD ASC in detail see interaction RIPK2 in detail Checked Checked Checked
CARD Bcl-10 in detail see interaction Bcl-10 in detail Checked Checked Checked
CARD Bcl-10 in detail see interaction CARD9 in detail Checked Checked Checked
CARD Bcl-10 in detail see interaction CARD10 in detail Checked Checked Checked
CARD Bcl-10 in detail see interaction CARD11 in detail Checked Checked Checked Checked
CARD Bcl-10 in detail see interaction CARD14 in detail Checked Checked Checked
CARD Bcl-10 in detail see interaction CARD12 in detail Checked
CARD Bcl-10 in detail see interaction CIAP2 in detail Checked
CARD Bcl-10 in detail see interaction RIPK2 in detail Checked Checked
CARD Bcl-10 in detail see interaction BinCARD in detail Checked Checked Checked Checked
CARD Bcl-10 in detail see interaction RAIDD in detail Checked Checked Checked
CARD Bcl-10 in detail see interaction CARMA1 in detail Checked Checked
CARD BinCARD in detail see interaction Bcl-10 in detail Checked Checked Checked Checked
CARD CARD10 in detail see interaction Bcl-10 in detail Checked Checked Checked
CARD CARD11 in detail see interaction Bcl-10 in detail Checked Checked Checked Checked
CARD CARD11 in detail see interaction CARD11 in detail Checked
CARD CARD12 in detail see interaction Caspase1 in detail Checked Checked Checked
CARD CARD12 in detail see interaction ASC in detail Checked Checked Checked
CARD CARD12 in detail see interaction CARD12 in detail Checked Checked
CARD CARD12 in detail see interaction Bcl-10 in detail Checked
CARD CARD12 in detail see interaction NLRP1 in detail Checked
CARD CARD12 in detail see interaction NOD2 in detail Checked
CARD CARD14 in detail see interaction Bcl-10 in detail Checked Checked Checked
CARD CARD16 in detail see interaction CARD16 in detail Checked
CARD CARD16 in detail see interaction Caspase1 in detail Checked Checked Checked
CARD CARD16 in detail see interaction RIPK2 in detail Checked Checked
CARD CARD16 in detail see interaction CARD18 in detail Checked Checked
CARD CARD16 in detail see interaction CARD8 in detail Checked Checked
CARD CARD16 in detail see interaction ASC in detail Checked
CARD CARD16 in detail see interaction CARD17 in detail Checked
CARD CARD17 in detail see interaction CARD16 in detail Checked
CARD CARD17 in detail see interaction CARD17 in detail Checked
CARD CARD17 in detail see interaction CARD18 in detail Checked
CARD CARD17 in detail see interaction Caspase1 in detail Checked
CARD CARD18 in detail see interaction Caspase1 in detail Checked Checked Checked
CARD CARD18 in detail see interaction CARD16 in detail Checked Checked
CARD CARD18 in detail see interaction RIPK2 in detail Checked
CARD CARD18 in detail see interaction CARD8 in detail Checked
CARD CARD18 in detail see interaction CARD17 in detail Checked
CARD CARD6 in detail see interaction CARD8 in detail Checked
CARD CARD6 in detail see interaction NLRP1 in detail Checked
CARD CARD6 in detail see interaction NOD1 in detail Checked Checked
CARD CARD6 in detail see interaction RIPK2 in detail Checked Checked
CARD CARD8 in detail see interaction CARD8 in detail Checked Checked
CARD CARD8 in detail see interaction Caspase9 in detail Checked Checked Checked
CARD CARD8 in detail see interaction CARD16 in detail Checked Checked
CARD CARD8 in detail see interaction Caspase1 in detail Checked Checked Checked
CARD CARD8 in detail see interaction CARD18 in detail Checked
CARD CARD8 in detail see interaction CARD6 in detail Checked
CARD CARD9 in detail see interaction Bcl-10 in detail Checked Checked Checked
CARD CARD9 in detail see interaction CARD9 in detail Checked
CARD CARD9 in detail see interaction RIPK2 in detail Checked Checked
CARD CARMA1 in detail see interaction Bcl-10 in detail Checked Checked
CARD Caspase1 in detail see interaction RIPK2 in detail Checked Checked Checked Checked
CARD Caspase1 in detail see interaction NOD1 in detail Checked Checked
CARD Caspase1 in detail see interaction CARD18 in detail Checked Checked Checked
CARD Caspase1 in detail see interaction CARD12 in detail Checked Checked Checked
CARD Caspase1 in detail see interaction CARD16 in detail Checked Checked Checked
CARD Caspase1 in detail see interaction Caspase1 in detail Checked Checked
CARD Caspase1 in detail see interaction CARD8 in detail Checked Checked Checked
CARD Caspase1 in detail see interaction ASC in detail Checked Checked Checked Checked
CARD Caspase1 in detail see interaction CARD17 in detail Checked
CARD Caspase1 in detail see interaction Caspase12 in detail Checked Checked
CARD Caspase1 in detail see interaction NLRP1 in detail Checked Checked
CARD Caspase1 in detail see interaction NOD2 in detail Checked Checked
CARD Caspase12 in detail see interaction Caspase12 in detail Checked
CARD Caspase12 in detail see interaction Caspase1 in detail Checked Checked
CARD Caspase12 in detail see interaction RIG-1 in detail Checked
CARD Caspase2 in detail see interaction RAIDD in detail Checked Checked Checked
CARD Caspase2 in detail see interaction NOL3 in detail Checked
CARD Caspase2 in detail see interaction NOD1 in detail Checked
CARD Caspase2 in detail see interaction NLRP1 in detail Checked
CARD Caspase2 in detail see interaction Apaf1 in detail Checked
CARD Caspase2 in detail see interaction Caspase2 in detail Checked Checked
CARD Caspase4 in detail see interaction Apaf1 in detail Checked
CARD Caspase4 in detail see interaction NOD1 in detail Checked
CARD Caspase4 in detail see interaction NLRP1 in detail Checked
CARD Caspase5 in detail see interaction NLRP1 in detail Checked Checked
CARD Caspase9 in detail see interaction Apaf1 in detail Checked Checked Checked Checked
CARD Caspase9 in detail see interaction CIAP1 in detail Checked Checked Checked
CARD Caspase9 in detail see interaction CIAP2 in detail Checked Checked Checked
CARD Caspase9 in detail see interaction NOD1 in detail Checked Checked Checked
CARD Caspase9 in detail see interaction CARD8 in detail Checked Checked Checked
CARD Caspase9 in detail see interaction Caspase9 in detail Checked
CARD CIAP1 in detail see interaction Caspase9 in detail Checked Checked Checked
CARD CIAP1 in detail see interaction RIPK2 in detail Checked Checked Checked
CARD CIAP2 in detail see interaction Caspase9 in detail Checked Checked Checked
CARD CIAP2 in detail see interaction RIPK2 in detail Checked Checked
CARD CIAP2 in detail see interaction Bcl-10 in detail Checked
CARD MAVS in detail see interaction MDA5 in detail Checked Checked
CARD MAVS in detail see interaction RIG-1 in detail Checked Checked
CARD MAVS in detail see interaction MAVS in detail Checked Checked
CARD MDA5 in detail see interaction MAVS in detail Checked Checked
CARD MDA5 in detail see interaction RIG-1 in detail Checked
CARD NLRP1 in detail see interaction Caspase2 in detail Checked
CARD NLRP1 in detail see interaction Apaf1 in detail Checked Checked Checked
CARD NLRP1 in detail see interaction NLRP1 in detail Checked
CARD NLRP1 in detail see interaction CARD12 in detail Checked
CARD NLRP1 in detail see interaction Caspase4 in detail Checked
CARD NLRP1 in detail see interaction Caspase5 in detail Checked Checked
CARD NLRP1 in detail see interaction CARD6 in detail Checked
CARD NLRP1 in detail see interaction Caspase1 in detail Checked Checked
CARD NOD1 in detail see interaction RIPK2 in detail Checked Checked Checked Checked
CARD NOD1 in detail see interaction Caspase1 in detail Checked Checked
CARD NOD1 in detail see interaction Caspase2 in detail Checked
CARD NOD1 in detail see interaction Caspase4 in detail Checked
CARD NOD1 in detail see interaction Caspase9 in detail Checked Checked Checked
CARD NOD1 in detail see interaction NOD1 in detail Checked Checked Checked
CARD NOD1 in detail see interaction CARD6 in detail Checked Checked
CARD NOD2 in detail see interaction RIPK2 in detail Checked Checked Checked Checked
CARD NOD2 in detail see interaction CARD12 in detail Checked
CARD NOD2 in detail see interaction Caspase1 in detail Checked Checked
CARD NOD2 in detail see interaction NOD2 in detail Checked Checked
CARD NOD2 in detail see interaction RIG-1 in detail Checked Checked Checked
CARD NOL3 in detail see interaction Caspase2 in detail Checked
CARD RAIDD in detail see interaction Caspase2 in detail Checked Checked Checked
CARD RAIDD in detail see interaction Bcl-10 in detail Checked Checked Checked
CARD RIG-1 in detail see interaction MAVS in detail Checked Checked
CARD RIG-1 in detail see interaction Caspase12 in detail Checked
CARD RIG-1 in detail see interaction NOD2 in detail Checked Checked Checked
CARD RIG-1 in detail see interaction MDA5 in detail Checked
CARD RIPK2 in detail see interaction CIAP1 in detail Checked Checked Checked
CARD RIPK2 in detail see interaction Caspase1 in detail Checked Checked Checked Checked
CARD RIPK2 in detail see interaction CIAP2 in detail Checked Checked
CARD RIPK2 in detail see interaction NOD1 in detail Checked Checked Checked Checked
CARD RIPK2 in detail see interaction NOD2 in detail Checked Checked Checked Checked
CARD RIPK2 in detail see interaction CARD16 in detail Checked Checked
CARD RIPK2 in detail see interaction CARD18 in detail Checked
CARD RIPK2 in detail see interaction CARD6 in detail Checked Checked
CARD RIPK2 in detail see interaction ASC in detail Checked Checked Checked
CARD RIPK2 in detail see interaction Bcl-10 in detail Checked Checked
CARD RIPK2 in detail see interaction CARD9 in detail Checked Checked
CARD RIPK2 in detail see interaction RIPK2 in detail Checked
DD ANK3 in detail see interaction FADD in detail Checked Checked
DD ANK3 in detail see interaction Fas in detail Checked Checked
DD DAPK1 in detail see interaction FADD in detail Checked
DD DAPK1 in detail see interaction TNFR1 in detail Checked
DD DAPK1 in detail see interaction UNC5B in detail Checked Checked
DD DR3 in detail see interaction TRADD in detail Checked Checked
DD DR3 in detail see interaction DR3 in detail Checked Checked Checked
DD DR3 in detail see interaction TNFR1 in detail Checked Checked
DD DR3 in detail see interaction FADD in detail Checked
DD DR4 in detail see interaction FADD in detail Checked Checked Checked
DD DR4 in detail see interaction TRADD in detail Checked Checked
DD DR4 in detail see interaction RIP in detail Checked Checked
DD DR4 in detail see interaction MADD in detail Checked Checked
DD DR4 in detail see interaction DR5 in detail Checked Checked
DD DR5 in detail see interaction FADD in detail Checked Checked Checked
DD DR5 in detail see interaction RIP in detail Checked
DD DR5 in detail see interaction TRADD in detail Checked Checked
DD DR5 in detail see interaction MADD in detail Checked Checked
DD DR5 in detail see interaction DR4 in detail Checked Checked
DD DR5 in detail see interaction DR5 in detail Checked
DD DR6 in detail see interaction TRADD in detail Checked
DD EDAR in detail see interaction EDARADD in detail Checked Checked Checked Checked
DD EDARADD in detail see interaction EDAR in detail Checked Checked Checked Checked
DD EDARADD in detail see interaction EDARADD in detail Checked Checked
DD FADD in detail see interaction Fas in detail Checked Checked Checked Checked
DD FADD in detail see interaction TRADD in detail Checked Checked Checked
DD FADD in detail see interaction TNFR1 in detail Checked Checked Checked
DD FADD in detail see interaction RIP in detail Checked Checked Checked
DD FADD in detail see interaction DR3 in detail Checked
DD FADD in detail see interaction DR4 in detail Checked Checked Checked
DD FADD in detail see interaction DR5 in detail Checked Checked Checked
DD FADD in detail see interaction PIDD in detail Checked
DD FADD in detail see interaction Myd88 in detail Checked
DD FADD in detail see interaction DAPK1 in detail Checked
DD FADD in detail see interaction ANK3 in detail Checked Checked
DD FADD in detail see interaction MALT1 in detail Checked
DD FADD in detail see interaction RIP1 in detail Checked Checked
DD Fas in detail see interaction FADD in detail Checked Checked Checked Checked
DD Fas in detail see interaction Fas in detail Checked
DD Fas in detail see interaction RIP in detail Checked
DD Fas in detail see interaction TRADD in detail Checked
DD Fas in detail see interaction ANK3 in detail Checked Checked
DD Fas in detail see interaction TNFR1 in detail Checked
DD IRAK1 in detail see interaction Myd88 in detail Checked Checked Checked
DD IRAK1 in detail see interaction IRAK1 in detail Checked
DD IRAK1 in detail see interaction IRAK2 in detail Checked Checked
DD IRAK1 in detail see interaction IRAK3 in detail Checked Checked
DD IRAK1 in detail see interaction NGFR in detail Checked Checked
DD IRAK1 in detail see interaction IRAK4 in detail Checked Checked
DD IRAK2 in detail see interaction Myd88 in detail Checked Checked Checked Checked
DD IRAK2 in detail see interaction IRAK1 in detail Checked Checked
DD IRAK2 in detail see interaction IRAK2 in detail Checked
DD IRAK2 in detail see interaction IRAK3 in detail Checked
DD IRAK2 in detail see interaction IRAK4 in detail Checked Checked
DD IRAK3 in detail see interaction IRAK1 in detail Checked Checked
DD IRAK3 in detail see interaction IRAK2 in detail Checked
DD IRAK3 in detail see interaction IRAK3 in detail Checked
DD IRAK3 in detail see interaction Myd88 in detail Checked
DD IRAK4 in detail see interaction Myd88 in detail Checked Checked Checked Checked
DD IRAK4 in detail see interaction IRAK1 in detail Checked Checked
DD IRAK4 in detail see interaction IRAK2 in detail Checked Checked
DD MADD in detail see interaction TNFR1 in detail Checked Checked
DD MADD in detail see interaction MADD in detail Checked
DD MADD in detail see interaction TRADD in detail Checked Checked Checked
DD MADD in detail see interaction PIDD in detail Checked
DD MADD in detail see interaction DR4 in detail Checked Checked
DD MADD in detail see interaction DR5 in detail Checked Checked
DD MALT1 in detail see interaction FADD in detail Checked
DD Myd88 in detail see interaction IRAK2 in detail Checked Checked Checked Checked
DD Myd88 in detail see interaction IRAK1 in detail Checked Checked Checked
DD Myd88 in detail see interaction Myd88 in detail Checked Checked
DD Myd88 in detail see interaction IRAK3 in detail Checked
DD Myd88 in detail see interaction FADD in detail Checked
DD Myd88 in detail see interaction IRAK4 in detail Checked Checked Checked Checked
DD Myd88 in detail see interaction NGFR in detail Checked
DD NF-kB1 in detail see interaction NF-kB2 in detail Checked Checked
DD NF-kB2 in detail see interaction NF-kB1 in detail Checked Checked
DD NGFR in detail see interaction IRAK1 in detail Checked Checked
DD NGFR in detail see interaction Myd88 in detail Checked
DD NGFR in detail see interaction TRADD in detail Checked Checked
DD PIDD in detail see interaction FADD in detail Checked
DD PIDD in detail see interaction MADD in detail Checked
DD PIDD in detail see interaction RAIDD in detail Checked Checked Checked Checked
DD PIDD in detail see interaction RIP in detail Checked Checked
DD RAIDD in detail see interaction RIP in detail Checked Checked
DD RAIDD in detail see interaction PIDD in detail Checked Checked Checked Checked
DD RIP in detail see interaction Fas in detail Checked
DD RIP in detail see interaction TNFR1 in detail Checked Checked Checked
DD RIP in detail see interaction TRADD in detail Checked Checked
DD RIP in detail see interaction FADD in detail Checked Checked Checked
DD RIP in detail see interaction RIP in detail Checked
DD RIP in detail see interaction RAIDD in detail Checked Checked
DD RIP in detail see interaction DR5 in detail Checked
DD RIP in detail see interaction DR4 in detail Checked Checked
DD RIP in detail see interaction PIDD in detail Checked Checked
DD RIP1 in detail see interaction FADD in detail Checked Checked
DD TNFR1 in detail see interaction TNFR1 in detail Checked
DD TNFR1 in detail see interaction TRADD in detail Checked Checked Checked Checked
DD TNFR1 in detail see interaction RIP in detail Checked Checked Checked
DD TNFR1 in detail see interaction FADD in detail Checked Checked Checked
DD TNFR1 in detail see interaction DR3 in detail Checked Checked
DD TNFR1 in detail see interaction MADD in detail Checked Checked
DD TNFR1 in detail see interaction DAPK1 in detail Checked
DD TNFR1 in detail see interaction Fas in detail Checked
DD TRADD in detail see interaction TNFR1 in detail Checked Checked Checked Checked
DD TRADD in detail see interaction FADD in detail Checked Checked Checked
DD TRADD in detail see interaction RIP in detail Checked Checked
DD TRADD in detail see interaction TRADD in detail Checked Checked
DD TRADD in detail see interaction DR3 in detail Checked Checked
DD TRADD in detail see interaction MADD in detail Checked Checked Checked
DD TRADD in detail see interaction DR4 in detail Checked Checked
DD TRADD in detail see interaction DR5 in detail Checked Checked
DD TRADD in detail see interaction DR6 in detail Checked
DD TRADD in detail see interaction Fas in detail Checked
DD TRADD in detail see interaction NGFR in detail Checked Checked
DD UNC5B in detail see interaction DAPK1 in detail Checked Checked
DED Caspase10 in detail see interaction FADD in detail Checked Checked Checked
DED Caspase10 in detail see interaction FLIP in detail Checked Checked Checked
DED Caspase10 in detail see interaction Caspase8 in detail Checked
DED Caspase10 in detail see interaction DEDD2 in detail Checked
DED Caspase8 in detail see interaction FADD in detail Checked Checked Checked Checked
DED Caspase8 in detail see interaction FLIP in detail Checked Checked Checked
DED Caspase8 in detail see interaction DEDD in detail Checked Checked
DED Caspase8 in detail see interaction PEA15 in detail Checked Checked
DED Caspase8 in detail see interaction Caspase8 in detail Checked Checked
DED Caspase8 in detail see interaction Caspase10 in detail Checked
DED Caspase8 in detail see interaction DEDD2 in detail Checked Checked
DED DEDD in detail see interaction Caspase8 in detail Checked Checked
DED DEDD in detail see interaction FADD in detail Checked Checked Checked
DED DEDD in detail see interaction FLIP in detail Checked Checked
DED DEDD in detail see interaction DEDD2 in detail Checked Checked
DED DEDD in detail see interaction DEDD in detail Checked Checked
DED DEDD2 in detail see interaction FLIP in detail Checked Checked
DED DEDD2 in detail see interaction Caspase8 in detail Checked Checked
DED DEDD2 in detail see interaction DEDD in detail Checked Checked
DED DEDD2 in detail see interaction DEDD2 in detail Checked Checked
DED DEDD2 in detail see interaction Caspase10 in detail Checked
DED FADD in detail see interaction Caspase8 in detail Checked Checked Checked Checked
DED FADD in detail see interaction Caspase10 in detail Checked Checked Checked
DED FADD in detail see interaction FLIP in detail Checked Checked Checked Checked
DED FADD in detail see interaction DEDD in detail Checked Checked Checked
DED FADD in detail see interaction PEA15 in detail Checked Checked Checked
DED FLIP in detail see interaction Caspase8 in detail Checked Checked Checked
DED FLIP in detail see interaction FADD in detail Checked Checked Checked Checked
DED FLIP in detail see interaction Caspase10 in detail Checked Checked Checked
DED FLIP in detail see interaction FLIP in detail Checked
DED FLIP in detail see interaction DEDD2 in detail Checked Checked
DED FLIP in detail see interaction DEDD in detail Checked Checked
DED PEA15 in detail see interaction Caspase8 in detail Checked Checked
DED PEA15 in detail see interaction FADD in detail Checked Checked Checked
PYD AIM2 in detail see interaction ASC in detail Checked Checked Checked
PYD AIM2 in detail see interaction AIM2 in detail Checked
PYD ASC in detail see interaction ASC in detail Checked Checked Checked
PYD ASC in detail see interaction Pyrin in detail Checked Checked Checked
PYD ASC in detail see interaction NLRP3 in detail Checked Checked Checked Checked
PYD ASC in detail see interaction NLRP12 in detail Checked Checked
PYD ASC in detail see interaction POP1 in detail Checked Checked Checked Checked
PYD ASC in detail see interaction NLRP2 in detail Checked Checked Checked Checked
PYD ASC in detail see interaction NLRP10 in detail Checked Checked
PYD ASC in detail see interaction POP2 in detail Checked Checked Checked
PYD ASC in detail see interaction NLRP1 in detail Checked
PYD ASC in detail see interaction AIM2 in detail Checked Checked Checked
PYD ASC in detail see interaction IFI16 in detail Checked
PYD ASC in detail see interaction NLRP7 in detail Checked
PYD IFI16 in detail see interaction ASC in detail Checked
PYD NLRP1 in detail see interaction NLRP2 in detail Checked
PYD NLRP1 in detail see interaction POP2 in detail Checked
PYD NLRP1 in detail see interaction ASC in detail Checked
PYD NLRP10 in detail see interaction ASC in detail Checked Checked
PYD NLRP10 in detail see interaction NLRP10 in detail Checked
PYD NLRP12 in detail see interaction ASC in detail Checked Checked
PYD NLRP2 in detail see interaction ASC in detail Checked Checked Checked Checked
PYD NLRP2 in detail see interaction NLRP1 in detail Checked
PYD NLRP2 in detail see interaction POP2 in detail Checked Checked Checked
PYD NLRP3 in detail see interaction ASC in detail Checked Checked Checked Checked
PYD NLRP3 in detail see interaction NLRP3 in detail Checked
PYD NLRP7 in detail see interaction ASC in detail Checked
PYD POP1 in detail see interaction ASC in detail Checked Checked Checked Checked
PYD POP2 in detail see interaction ASC in detail Checked Checked Checked
PYD POP2 in detail see interaction NLRP2 in detail Checked Checked Checked
PYD POP2 in detail see interaction NLRP1 in detail Checked
PYD Pyrin in detail see interaction ASC in detail Checked Checked Checked
(Link: click this icon to show interactions only between the two corresponding DDs)